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Over-the-Counter Medicines

Misuse of over-the-counter medications like cough syrups, sleep aids, and pain relievers can lead to dependence.

Published: November 25, 2025
Last Edited: February 17, 2026
15 min read
BZ

Written by

Benjamin Zohar, NCACIP

Nationally Certified Advanced Addiction Intervention Professional

EZ

Edited by

Ezra Zohar, M.S. Ed.

Editorial Director

BM

Medically Reviewed by

Brandon McNally, RN

Medical Reviewer, ICU Critical Care Nurse

Published: November 25, 2025
Last edited: February 17, 2026
15 min read

How Over-the-Counter Medicines Affects You

DXM (cough syrup) causes dissociation and hallucinations at high doses. Loperamide (anti-diarrheal) abused for opioid-like effects. Antihistamines cause sedation and hallucinations. All cause organ damage.

Duration & Timeline

DXM effects last 3-6 hours. Loperamide effects last 10-20 hours. Withdrawal symptoms develop with chronic use, particularly with DXM and loperamide.

Specific Health Risks

DXM: Serotonin syndrome, psychosis, brain lesions. Loperamide: Fatal heart arrhythmias, cardiac arrest. Antihistamines: Seizures, cognitive impairment, anticholinergic toxicity.

Over-the-Counter Medicines Statistics & Research

  • • SAMHSA reports 3.1 million Americans aged 12+ misused OTC medicines in 2022, with DXM being most common
  • • FDA issued warnings on loperamide misuse after documented cardiac deaths; abuse increased 91% from 2012-2016
  • • Poison Control data shows 6,000+ cough medicine misuse cases annually, with 40% requiring emergency department care
  • • Adolescent DXM misuse correlates with progression to other substance use, per NIDA longitudinal studies

Sources: NIDA, SAMHSA, CDC, DEA, FDA, peer-reviewed medical journals. See full references below.

Frequently Asked Questions

Why Choose Professional Treatment in New York

Professional addiction treatment provides the medical supervision, therapeutic support, and structured environment necessary for successful recovery from over-the-counter medicines. Evidence-based treatment programs address both the physical and psychological aspects of addiction.

Treatment centers throughout Long Island and New York offer specialized programs accredited by The Joint Commission and licensed by the New York State Office of Addiction Services and Supports (OASAS). These facilities combine medical care, evidence-based counseling, and ongoing support to ensure the best possible outcomes for lasting recovery.

According to data from the New York State OASAS, treatment completion rates are highest when individuals receive comprehensive care that includes medical management, individual therapy, group support, and family involvement in the recovery process.

Medical References & Sources

This page contains information sourced from peer-reviewed medical literature, federal health agencies, and accredited medical institutions to ensure accuracy and compliance with E-E-A-T (Experience, Expertise, Authoritativeness, and Trustworthiness) standards.

  1. Lessenger, J.E., & Feinberg, S.D.. "Abuse of Prescription and Over-the-Counter Medications." Journal of the American Board of Family Medicine, 2008 DOI: 10.3122/jabfm.2008.02.070139. Available at: https://doi.org/10.3122/jabfm.2008.02.070139
  2. Food and Drug Administration (FDA). "Misuse of Over-the-Counter Cough and Cold Medicines." FDA Consumer Updates. Available at: https://www.fda.gov/drugs/information-drug-class/misuse-over-counter-cough-and-cold-medicines
  3. Substance Abuse and Mental Health Services Administration (SAMHSA). "Misuse of Over-the-Counter Medications Among Youth." SAMHSA Publications. Available at: https://www.samhsa.gov/data

Medical Disclaimer

The information provided on this page is for educational purposes only and should not be considered medical advice. This page does not provide medical diagnoses, treatment prescriptions, or clinical recommendations. Always consult with qualified healthcare professionals for diagnosis and treatment of substance use disorders. If you are experiencing a medical emergency, call 911 immediately.

This content was written by certified addiction professionals and reviewed by licensed medical practitioners to ensure accuracy and adherence to current clinical guidelines. Last fact-checked: July 6, 2026.

If you or someone you know is struggling with substance use, you can reach our 24/7 confidential Long Island Rehab Helpline at 631-762-3763 for free, confidential information and treatment referral.

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